copper concentration cell
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copper concentration cell

Characterization of the basic charge variants of a human IgG1: effect of copper concentration in cell culture media. We report a case study of an IgG1 with a unique basic charge variant profile caused by C-terminal proline amidation on either one or two heavy chains. The proline amidation was sensitive to copper ion concentration in the production media during cell culture: the higher the Cu ( 2+) ion …

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